Types of organic reaction mechanisms taken in relation to types of organic functional groups, effects on their stability. Use in pharmacy. Other physicochemical properties, solubility, absorption, distribution and excretion when found in drug molecules. Functional groups to be treated include Aldehydes and Ketones, alcohols and phenols, carboxylic acids and their derivatives (amides, esters, acid anhydrides, Acyl halides) and sulphonic acid, also to be treated and amines and are imines, nitriles, nitro and nitroso groups and azo-compounds.

 General review of the concept of aromaticity in benzene and how this affects substitution in such structures.

 Stereochemistry

 Review of total concept of stereoisomerism as distinct from isomerisms of other types-optical and geometrical isomerism, chiral and achiral molecules, stereoisomerism and molecular conformation in relation of drug action through drug-receptor interaction. Biological examples, Determination of configuration- spectroscopic methods,

 Resolution of racemic mixtures and importance in Pharmacy using named medicinal examples. Optical rotatory dispersion and its uses. Importance of stereochemistry in terpenes.


Level of Study: 300 Level