The department of Chemical Pathology in the University formally came into existence in 2001/2002 session as an independent and autonomous department within the College of Health Sciences and as an integral part of the School of Clinical Medicine. Chemical Pathology is one of the five independent departments created in the Sciences of Pathology complex.

AIMS AND OBJECTIVES

 The aims and objectives of the course are:

  To enable medical students and other students in CHS acquire theoretical and practical knowledge and skills in the application and practice of chemical pathology in clinical medicine. 

   To provide a course of programmes which enables students to recognize and describe the biochemical derangements in disease associated with abnormalities in metabolism of body constituents.

  To enable students to understand the principles of laboratory investigations and interpretation of results of biochemical investigations in order to clarify or establish diagnosis.

To provide diagnostic laboratory services to the Igbinedion University Teaching Hospital (IUTH) for patients care.



Introduction to Laboratory Medicine/Chemical Pathology

                        Meaning and scope of chemical Pathology

                        Collection and preservation of samples for biochemical tests

                        The concept of normal or reference values

                        Units of expressing results. Interpretation of results

                        The use of the Laboratory in clinical patient care.

 

Normal renal physiology, pathophysiology of renal diseases

                        Glomerulonephritis, Nephrotic syndrome, Fanconi syndrome

                        Renal function tests in clinical practice

                        Renal function tests in clinical practice

                        The value of chemical urinalysis in clinical medicine

 

Fluid and electrolyte balance in health and disease Acid-base homeostasis and its disorders in diseased conditions

Principles of biochemical genetics and inborn errors of metabolism, Introduction to medicalgenetics, Chromosomes and DNA replication, Regulation of Gene Expression, Cloning and Sequencing of DNA, Molecular diagnostics. Inborn errors of Amino acid metabolism

                        Alkaptonuria, PKU (Phenylketonuria), Albinism

                        Cystinuria, Hartnup’s disease, Maple syrup urine disease.

 

Inborn errors of Carbohydrate metabolism

                          Galactosaemia, Fructosuria, Glycogen storage diseases


Level of Study: 300 Level

Haem biosynthesis

The porphyries and their classification

Chemical Pathology of Nutrition to include vitamins, minerals, trace elements requirements Protein and protein-calorie malnurtrition

 Haematological Chemistry – iron metabolism, Folate and Vitamin B12 metabolism to highlight their association with haematological disorders

 Purine metabolism and Gout

 Chemical Pathology of the Gastrointestinal Function and its disorders to include the malabsorption syndrome.

 Plasma Proteins and paraproteinemias.

 Lipids and lipoprotein metabolism

 Clinical enzymology to include diagnostic enzymology in hepatic, cardiac, muscular and bone disorders.

 Bilirubin metablism and Jaundice. Liver function tests to assess hepatic function.

 Hypoglycaemic and hyperglycaemic syndromes. Diabetes Mellitus, its diagnosis, management and control.

 Introduction to Clinical Endocrinology, current concepts of mechanism of hormonal action at the cellular level.


Level of Study: 400 Level

Haem biosynthesis

 

The porphyrias: Their biochemical and

Clinical classifications

 

PRACTICALS

 

Hypoglycaemia – causes and investigations

 

 

 

 

PRACTICALS

 

 

 

 

Hyperglycaemia – causes and investigations

 

 

 

 

Diabetes  mellitus,  diagnosis,  management  and

control

 

 

 

 

 

Oral glucose tolerance Test

 

 

Patterns of curves and disease conditions

 

 

 

 

PRACTICAL

 

 

 

 

Bilirubin metabolism

 

 

 

Jaundice and its classification

 

 

 

 

 

PRACTICALS

 

 

 

 

Normal Hepatic physiology

 

 

Liver function and its disorders

 

 

 

 

 

 

 

 

PRACTICALS

 

 

 

 

Continuous Assessment Test II

 

 

Clinical enzymology – Introductory

 

 

 

 

 

Diagnostic enzymology in hepatic disease

 

Diagnostic enzymes in cardiac disorders

Diagnostic enzymes in muscular dystrophies

Diagnostic enzymes in cardiac disorders

Diagnostic enzymes in cardiac disorders

Diagnostic   enzymes   in   some   miscellaneous

disorders including red cell enzymes in clinical

diagnosis

 

NUTRITION: Major classes of food and in health

and disease – proteins carbohydrates and fat in

energy requirement

 

Kwashiorkor and marasmus

 

Micro nutrients requirements – Vitamins and trace

elements in health and in disease

Haematological biochemistry: I iron metabolism

PRACTICALS

 

Iron metabolism (contd)

 

PRACTICALS

 

Haematological biochemistry II: Folate & Vit. B12

metabolism

 


Level of Study: 400 Level

Calcium, Phosphorous, Magnesium metabolism in health and disease.

Hypothalamic and Pituitary hormones in health and disease.

Adrenocortical hormones and their disorders in disease

Laboratory investigation of the hypothalamic-pituitary adrenal axis.

Adrenal medulla and its hormones: Phaechromocytoma, neuroblastoma.

Congenital adrenal hyperplasia

Thyroid function – Normal and Pathological functions. Thyroid function tests. Gonadal endocrinology (male and female)

 The APUD system

 Biochemical examination of CSF.

 Biochemistry of malignancy – tumour markers

 Total parenteral nutrition and its laboratory monitoring

 Radioisotopes in Laboratory Medicine



Level of Study: 400 Level